Microbes are generally associated with infection, and the usual response to their mere presence is to eradicate them as quickly as possible. For example, the “no-rinse soap” used during space travel mainly consist of antimicrobials, i.e. chemicals that kill microbes, with the aim to remove bacteria on the skin.
It is correct that microbes can cause disease, but it is microbes that created an environment and an atmosphere on Earth that allow plants and animals to exist. Microbes are literally everywhere, and we ourselves depend upon microbes to keep our external facing surfaces healthy and to help with the breakdown of food in our gut and production of substances that our body needs. The microbes form actual communities with thousands of species in and on us, for example the gut, respiratory and skin microbiomes, and these communities collaborate with our immune systems.

​To give an idea of their importance, data suggest that it is the pollution from antimicrobials that is the primary responsible for climate change because their impact is very broad and reduces the microbial diversity and changes the microbial balance. Similarly, studies indicate that antibiotics have long-term impact on our health, and they have been shown to increase the frequency of cancer, diabetes, asthma as well as functional impairments in children’s development, immune function, and cognition. Poor gut health, which usually means an unbalanced and low diversity microbiome, has also been associated with mental health problems including depression and anxiety as our gut microbiome is responsible for producing substances needed for normal brain function.
On the International Space Station skin issues and problems with wound healing have been reported. Microgravity and radiation have generally been assumed to be responsible for this and the fact, that “no-rinse-soap” is a cocktail of antimicrobials, has received practically no attention. Antimicrobials are traditionally used for treating wounds, but the US FDA reported in 2016 and again in 2022 that they are ineffective in treating wounds, and studies have demonstrated that antimicrobials directly impair healing and that a healthy wound microbiome is required for healing to take place. These novel conclusions banning antimicrobials in skin care and wound healing are further supported by the positive findings with a new technology, MPPT (micropore particle technology), which acts by regulating the wound microbiome without killing anything. MPPT has been able to achieve 100% wound closure rates, including in complicated wounds and in people with impaired immune function. This observation shows that approaches that support the collaboration between the microbes and the immune system can be much more effective than the traditional, old blanket-bombing approach of eradicating all microbes, which renders the skin debilitated and less resilient.

These observations are relevant to space travel, in terms of both the environment onboard and clothing, food and methods of ”washing”. Our bodies have evolved on Earth, where microbes were and are present, and our evolution has benefited from this as the microbes assist in protecting our surfaces and in delivering nutrients and critical compounds needed for our health. This dependence persists, even if we decide to leave Earth for shorter or longer periods of time. It is therefore a necessity, particularly for deep space travel, which does not permit us returning to Earth periodically to update our microbiome, to develop environments and procedures onboard that can sustain our microbial requirements.
These considerations are based on an article recently published in Frontiers in Public Health, which focuses on the role of antimicrobials in causing climate change from severely damaging the Earth’s microbiome. The impact of antimicrobials on the Earth microbiome and the microbiome inside a space station are comparable as they are both closed systems. It is consequently important to consider the essentiality of the microbial environment, when planning human life outside the Earth’s environment.

When scrolling through the endless nonsense recently that appears on Facebook, I came across a rare post of interest detailing the remarkable work of French geologist Michel Siffre, who died a year ago this Sunday (24 August 2024), aged 85 years. In 1972, Siffre conducted an extraordinary isolation experiment in which he lived alone for 180 days in a cave 440 feet underground. He had no sunlight, no clock, and no contact with any other person, having only basic supplies, a sleeping bag, and instruments for recording his activities and observations.
His aim was to study how the human mind and body behave when deprived of all natural time cues. The results of this work, now more than 50 years old, continue to be relevant for research into human endurance, circadian rhythms, and the psychological effects of extreme isolation. They are also especially relevant for human space exploration, with space agencies considering the realities of sending people to live for months, or even years, in sealed environments on the Moon or Mars.

Initially, Siffre relied on hunger and fatigue to regulate his days, but within weeks it was observed that his perception of time changed. He often believed a day had passed when nearly two had gone by. His body abandoned the 24-hour cycle, adopting a 36-hour waking period followed by 12 hours of sleep.
Scientists monitoring the experiment saw this as evidence that humans have an internal clock that can operate independently of the Sun. The changes, however, came with cognitive and psychological costs, like hallucinations, difficulty speaking, memory lapses, and a need to create artificial social interaction, such as talking to insects or to himself. By the time the experiment ended, Siffre believed only 151 days had passed, rather than the actual 180 days.

Life Without a Sunrise - Astronauts aboard the International Space Station (ISS) see 16 sunrises every Earth day. This constant cycling of light and dark is managed by strict schedules, carefully calibrated lighting systems, and oversight by mission control, ensuring that body clocks remain aligned with a 24-hour rhythm. Without such controls, circadian rhythms can rapidly drift, affecting alertness, decision-making, and even physical health.

The webinar, organised by InnovaSpace Director Prof Thais Russomano, was presented by 4 students from the Remote Medicine iBSc program, National Heart & Lung Institute, Imperial College London, and in association with the MVA (Moon Village Association). The focus of the event was on one of the most critical aspects of future lunar habitation: human health.
Join the student panel as they explore the unique environment of the Moon, the history of its human exploration from NASA Apollo Mission first steps to future Artemis plans, its potential impact on human physical health and mental well-being, Moon research and Earth-based space analogues, and research limitations and gaps in the knowledge.
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Congratulations to the presenters - Manvi Bhatt, Nareh Ghazarians, Diya Raj Yajaman, & Elvyn Vijayanathan - and good luck with your future careers. 

​Bubbles are a common occurrence in liquids, ranging from the simple rising ones to the turbulent ones that playfully form. However, behind their seemingly innocent façade lies a lesser-known and more complex side—cavitation bubbles. These unassuming bubbles possess the capacity to wreak havoc, generating destructive shock waves, emitting bursts of light, and even exhibiting unique chemical properties. In this article, we will delve into the intricate mechanics of cavitation bubbles, shedding light on their rapid collapse phase and the fascinating behaviours that accompany it.
 
Cavitation bubbles undergo a sequence of stages, each contributing to their overall behaviour. It all begins with the inception of minuscule gas or vapor pockets known as nuclei within the liquid. These nuclei can emerge from various sources such as dissolved air, impurities, or surface irregularities. As the liquid traverses areas of lower pressure, these nuclei gradually expand into larger bubbles due to vaporisation—a process akin to boiling, yet without the actual boiling point being reached.

​The movement of cavitation bubbles is governed by the interplay between forces within the fluid flow and the intrinsic characteristics of the bubbles themselves. Forces such as drag, buoyancy, pressure gradients, and interactions with solid surfaces dictate their trajectories. Some bubbles ascend due to buoyancy, while others become entrapped in turbulent flows, swirling unpredictably. Along their trajectory, pressure gradients act as guiding forces, steering the bubbles in specific directions.
 
Yet, the most intriguing facet of cavitation bubbles lies in their eventual collapse. As these bubbles transition from low-pressure regions to areas of higher pressure, they face escalating external pressure. This rapid compression leads to their dramatic collapse, referred to as the bubble collapse phase. During this phase, the confined space witnesses the generation of extreme pressures and temperatures, resulting in the formation of shock waves, microjets, and even flashes of light. This release of energy significantly contributes to the inherently destructive nature of cavitation, capable of causing damage to nearby surfaces.

The collapse transpires in a fleeting instant, lasting only microseconds. The energy unleashed results in temperatures surpassing the sun's surface heat and pressures that rival the deepest ocean trenches. Shock waves and microjets formed in this dramatic event have the power to erode metals, damage propellers, and influence chemical reactions within the surrounding liquid. Researchers are particularly enthused by the potential applications of this released energy, spanning from catalysing intricate chemical reactions to advancing medical treatments.
 
Despite extensive research, comprehending the intricate dynamics of cavitation bubbles remains a formidable challenge. The intricate dance of fluid dynamics, coupled with the unpredictable nature of turbulence, renders achieving comprehensive understanding an ongoing pursuit. Researchers employ numerical simulations and experiments to gain insights, yet many aspects of this phenomenon are still awaiting exploration. Unravelling the mechanisms underlying bubble collapse and its aftermath stands as a continuing endeavour, driven by the desire to harness its energy while mitigating its potential harm.

Who are the authors?
Experts in this field from several space agencies => NASA, IBMP (Russia), ESA
Funding => NASA, under the Human research program. Part of the multi-institution international fluid shifts study.

What is interesting about this paper/ Why would the medical space community be interested in this?
New pathology, not diagnosed before. Potentially massive implications for future long duration missions. LBNP could potentially be a countermeasure to enhance venous blood flow or improve cerebral venous outflow.

The research question.
Loss of hydrostatic gradient and variation on Earth, sustained fluid redistribution. Effect on cerebral venous drainage/blood flow. Possible mechanism linked to SANS? Increased risk of clot formation due to static/retrograde flow?
Aims:

1. Characterise cerebral venous outflow during spaceflight vs. +1Gz (in left IJV)
2. Evaluate effect of LBNP on cerebral venous outflow

Why is this research question important?
Static/stagnant flow can predispose individuals to thrombus formation. Long lasting effects of thrombi for astronauts, potentially affecting crew performance (i.e. risk of anticoagulation, emboli, then leading to reduced performance affecting the crew and mission).

The study design.
Primary research => prospective cohort study (follow a similar patient group over time, comparing a particular outcome). Subjects were 11 astronauts, on the ISS.
Method:
Ultrasonographic assessment of left IJV (IJV are main conduits of cerebral drainage)
                        - pre flight (3 positions, seated, supine & head down tilt)
                        - at approximately D50 and D150 of spaceflight
                        - with and without LBNP (approx the same days, Russian Chibis-M LBNP)​
​

My name is Lucas, I am a doctor in the UK working in anaesthetics (or Anaesthesiology for any American readers) and intensive care medicine. I have had an interest in space medicine for over 10 years now, inspired by none other than Prof Thais Russomano who has mentored me over the years and still does. My Master’s dissertation (back in 2009) focused on CPR (cardiopulmonary resuscitation) methods in microgravity, with my continued research interest surrounding critical care in space. I am careful to say that I am a doctor with an interest in space medicine and physiology, as opposed to a ‘Space Doctor’ – as there are many individuals out there who have committed many more years than I have to this field and are vastly more experienced than I am! A club I aspire to join one day.

The idea of this blog, or series of blogs, is to look at some of the latest research in space physiology and space medicine, then consider how this will play out clinically. With a particular focus on critical care and potentially worst-case scenarios when in space (or microgravity environment). Something all doctors will have done in their careers; we are equipped with the skills to critically appraise papers and then ask if they are clinically relevant, or how will it change current practice.

​Over the last 60 (ish) years of human space flight, there is lots of evidence to show that there are many risks when the human body has prolonged exposure to microgravity, which can affect most body systems – eyes, brain, neuro-vestibular, psychological, heart, muscle, bone, kidneys, immune system, vasculature, clotting and even some that we haven’t fully figured out yet. But then what needs to be done is to tease out how clinically relevant are these from the research, how could that potentially play out if you were the doctor in space, then how to mitigate that risk and potentially treat it.

'Life' is the most dynamic entity known to humanity and is central to our existence. In this, 'Space Sciences' is one of the most multi-disciplinary fields of human endeavour. Therefore, to celebrate the interdependence between 'Life' and 'Space', we, as a group of space enthusiasts, initiated a non-profit community named "Life- To & Beyond" or "L-T&B" on the 8th of February, 2022.

Why us?
​
Life- To implies Astrobiology, i.e. the scientific study of the origin, evolution, and distribution of life in the cosmos, and Life- Beyond implies Space-Allied Studies, i.e. humanity's current efforts to move beyond our planet and simultaneously conserve its novelty. Thus, as our name implies, we aspire to figure out more about Life and Space, which, in turn, are the two sides of the same coin, known as the 'Universe'.

Our Vision and Mission:

We, the members of team L-T&B, firmly believe that 'to explore is to be Human', and so, we rejoice 'Life' as a 'Cosmic Phenomenon' by attempting to:
• Figure out the chronicle of our past (i.e. from the big bang and even beyond to conscious life on earth);
• Work on our present (i.e. our current efforts to move beyond our planet and at the very same time conserve its unique richness); and 
• Create a glorious future for humans (i.e. our ultimate fate in the universe).

Furthermore, we have the vision to generate awareness and create an impact in every community and country in the world by creating local or accessible opportunities for learning and research concerning Space sciences and STEAM fields with a special focus on Astrobiology and Space-Allied Studies
(i.e., Space Pharmacy, Space Biotechnology, Analog missions, Space robotics, space architecture, etc.).
To turn our vision into a reality, we vow to engage in Research, Communication, and Outreach concerning our focus areas. Additionally, to spice up our enterprise, we work towards bringing about an intra-, inter-, multi-, and trans-disciplinary approach in whatever we do, including making quality education and research opportunities (and facilities) available to all. To fuel this initiative, we have taken the onerous on us to share information about events and opportunities related to space sciences with all.
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Cardiopulmonary resuscitation (CPR) is a well-established part of basic life support (BLS), having saved countless lives since its first development in the 1960s. External chest compressions (ECCs), which form the main part of BLS, must be carried out until Advanced Life Support can begin. It is essential that ECCs are performed to the correct depth and frequency to guarantee effectiveness. The absence of gravity during spaceflight means that performing ECCs is more challenging.
The likelihood of a dangerous cardiac event occurring during a space mission is remote, however, the possibility does exist. Nowadays, the selection process for space missions considers individuals at ages and with health standards that would have prohibited their selection in the past. With increased age, less stringent health requirements, longer duration missions and increased physical labour, due to a rise in orbital extravehicular activity, the risk of an acute life-threatening condition occurring in space has become of greater concern. The advent of space tourism may even enhance this possibility, with its popularity set to rise over the coming years as private companies test their new technology.

Therefore, space scientists and physicians will have a greater responsibility to ensure space travellers, whether professional astronauts or space tourists, are adequately trained and familiarised with extraterrestrial BLS and CPR methods. Recently, work has been undertaken to develop methods of basic and advanced life support in microgravity and hypogravity, and several CPR techniques have been developed and tested. This blog presents one of these, the Evetts-Russomano MicroG CPR Method.

​In the Evetts-Russomano (ER) method, the rescuer can respond immediately, as it requires no additional CPR equipment/medication or the use of a restraint system. To assume the position, the rescuer places their left leg over the right shoulder of the patient and their right leg around the patient’s torso, allowing their ankles to be crossed approximately in the centre of the patient’s back; this is to provide stability and a solid platform against which to deliver force, without the patient being pushed away. From this position, chest compressions can be performed while still retaining easy access to perform ventilation. When adopting the ER CPR method, the rescuer must be situated in a manner that also allows sufficient space on the patient’s chest for the correct positioning of their hands to deliver the chest compressions.

Free Resource: Extraterrestrial CPR and Its Applications in Terrestrial Medicine
Authors: Thais Russomano, Lucas Rehnberg
In book: Resuscitation Aspects, Ed: Theodoros Aslanidis
Publisher: IntechOpen 2017
See Download Link at https://www.innovaspace.org/chapters.html

In this week that saw the world celebrate International Women's Day, the InnovaSpace team welcome news about the work of Dr Lucia Hartmann & Jasmin Mittag, with a new concept for the shape of future space travel and a desire to promote equality - an ethos we fully support!

​The first spacecraft in a V-shape is not only a symbol for more diversity in space, but also state-of-the-art and thus more sustainable. The “Vulva Spaceship” designed by “WBF Aeronautics” represents inclusivity, varying from the traditional shapes. Thus, the project adds another dimension to the representation of humanity in space and is communicating to the world that anyone has a place in the universe, regardless of physical characteristics.

Dr. Lucia Hartmann, Head of “WBF Aeronautics” and inventor of the “Vulva Spaceship” reports from her research: “The spaceship’s shape is surprisingly aerodynamic, creating way less drag when the vehicle punches through the Earth’s atmosphere. Due to this optimized V-shape, it guarantees maximum fuel efficiency with an exterior made of reinforced carbon which enables it to withstand the most extreme temperatures.” “WBF Aeronautics” wants to inspire space travel to be open to modern forms and to realise equal opportunities across the universe.

“WBF Aeronautics” is a collaboration between Dr. Lucia Hartmann and her team and “Wer braucht Feminismus?” (WBF). Dr. Lucia Hartmann started her research work about spaceships and discovered that a spaceship varying from traditional shapes, would be more aerodynamic and create less drag, thus being more sustainable.

She reached out to us for the purpose of a collaboration and for us to do the media work as there is much more to it than just the scientific aspect. On the one hand, the topic is sensitive, but on the other hand, it also holds great opportunities. The symbol of a Spaceship in a V-shape represents more diversity in space. The project adds another dimension to the representation of humanity in space. 

We believe that equality even has a place in space. It’s time for new symbols in the universe. 
​

Encerramos após 11 dias (ou 11 sois, como denominamos o dia em Marte) a missão análoga (virtual) #96, celebrando quatro anos do estabelecimento da Estação Habitat Marte. Tive o privilégio de representar a InnovaSpace nessa experiência, que se revelou produtiva e instigante.
As missões virtuais foram criadas em função da pandemia de COVID-19, como forma de manter a estação operando e fomentando o intercambio de experiências e informações sobre Marte e os desafios de se chegar ao planeta vermelho. A pioneira estrutura análoga, entretanto, é muito mais que isso. Localizado no agreste do Rio Grande do Norte, na cidade de Caiçara do Rio do Vento, o Habitat Marte é uma base física onde as condições inóspitas do terreno e algumas características relacionadas ao solo local propiciam um sítio ideal ao estabelecimento de missões com variados focos de pesquisa. Uma palavra que está sempre presente é sustentabilidade.

Numa missão virtual, um clima de imersão e interação entre os cinco tripulantes é estimulado pela rotina de atividades como coleta de dados, apresentação de relatórios sobre o estado físico e mental e, ao longo dessa jornada, vai se criando uma atmosfera de imaginação coletiva acerca da presença no planeta vermelho, com o benefício da dinâmica das relações por interações remotas. Cada tripulante recebeu a incumbência de ser responsável por uma das estruturas críticas da estação (Estação Central e Centros de Engenharia, Saneamento, Saúde e Lançamento). Ao final, cada membro da missão fez uma apresentação sobre sua área de responsabilidade, encerrando a missão.
Minha experiência pessoal na missão virtual foi ser o responsável pelo Centro de Lançamento (e retorno). Além de estar comprometido com a operacionalidade dessa área, incluí na rotina de relatórios o status “go & no go”, em função das condições técnicas ou meteorológicas, de modo a manter a estação ciente da viabilidade de um lançamento emergencial. A rotina de envio de relatórios é o grande gerador de valor para a simulação e vai ao encontro dos aspectos humanos: discutíamos situações que não decorreram de inputs do simulacro. Trocávamos informações e fotos, fomos inspirados a viver uma realidade paralela e a explorar nossa criatividade.

​Conversas sobre a missão e até pessoais foram constantes através de plataforma de mensagens e me mantiveram em constante “presença” naquela estação. Os dois relatórios de rotina diários (meteorologia e condições pessoais, como saúde, motivação, estado mental e satisfação com a missão e suas especificidades) eram enviados por um aplicativo e nos lembravam da nossa responsabilidade na jornada. Há potencial para ainda mais integração, pois nenhuma missão é igual à outra. Quem sabe, no futuro, um ambiente visual via aplicativo que possa até ser compartilhado com óculos de realidade virtual e celular não elevem ainda mais esses efeitos?

​Minha conclusão foi a de que estímulo ao pensamento, diversidade e o fator lúdico já são uma ferramenta de integração e compromisso com a missão de grande valor.
Parabéns aos tripulantes da Missão 96 e em especial ao Prof. Julio Rezende, pelo pioneirismo, determinação e criatividade. Próximo passo: a missão presencial!