 Autores: Beatriz Helena Ramos Reis*, Bruno Veiga Fontes de Carvalho*, Prof Jonas Lírio Gurgel**, Prof Flávia Porto**Instituto de Educação Física e Desportos, Universidade do Estado do Rio de Janeiro (UERJ)
 A pandemia de COVID-19 gerou a necessidade de utilizar medidas de distanciamento social para que haja a redução da disseminação do novo coronavírus. Contudo, têm-se percebido prejuízos na saúde física e mental dos indivíduos, porque a mudança brusca na rotina resultou em um novo estilo de vida das pessoas, que passaram a viver em confinamento. Aumento de preocupações, ansiedade, tristeza prolongada e sedentarismo são algumas das consequências ocasionadas ou agravadas pelo isolamento. Como forma de minorar esses efeitos, o exercício físico continua sendo reconhecido como uma estratégia não-medicamentosa eficaz que auxilia na prevenção e no tratamento de doenças físicas, metabólicas e/ou psicológicas. Entretanto, a suspensão e a limitação do uso de estabelecimentos, como academias de ginástica e clubes esportivos, para evitar aglomeração, levaram muitas pessoas a praticar atividades físicas regulares em casa. Nesse contexto, percebeu-se um fenômeno interessante na internet, que foi o aumento da busca por informações online. O Google Trends, por exemplo, é um recurso que expõe os termos mais pesquisados em diferentes lugares do mundo e revela sua popularidade em uma escala de 0 a 100. Nele, foi possível identificar o aumento da busca por informações relacionadas às consequências e necessidades geradas pela pandemia. Nesse contexto, vimos que, no Brasil, as buscas pelo termo “exercício físico em casa”, em Português, antes de março de 2020, teve popularidade baixa (oscilando na escala entre 0% e 25% de procura via Google). Após esse mês, quando se iniciou o distanciamento social no país, a busca pelo termo oscilou, aproximadamente, entre 40% e 100% até o momento atual. Ao analisar o termo “physical exercise at home”, em Inglês, notou-se que, em janeiro de 2020, as buscas estavam entre 0% e 25%. De fevereiro até maio deste ano, as buscas estiveram entre 25% e 100%, diminuindo em junho, momento em que vários países afrouxaram as regras de isolamento. Ao observar esses dados, notamos um aumento considerável na popularidade dos termos durante esse período, demonstrando um maior interesse de internautas sobre o assunto. Essas oscilações parecem ter relação com o fechamento e abertura de comércio e demais atividades no mundo.  Interessante também mencionar a necessidade de adaptar os exercícios a ser realizados em casa. Dessa forma, percebeu-se que o interesse por equipamentos esportivos para realizar exercícios físicos em casa também aumentou, sendo demonstrado nas buscas no Google. A pesquisa pelo termo “equipamentos para atividade física”, nos dois primeiros meses desse ano, estava próxima a zero em níveis de interesse; já em março, o interesse aumentou bastante, chegando a atingir 100 no mês de abril. Em todo mundo, o termo “equipment for physical activity”, pesquisado na língua inglesa, mostrou pico de interesse (100 na escala) no mês de fevereiro e menor interesse próximo ao início de junho (0 na escala). Como a pandemia ainda não está controlada, inclusive com previsão de novas ondas de contágios e mortes, é bem provável que os hábitos das pessoas mudem, realmente, como forma de adaptação à nova realidade. Apesar da reconhecida resiliência das pessoas, não se pode negar que os prejuízos psicológicos são evidentes e, muitas vezes, é até difícil entender esses sentimentos e lidar com a magnitude que podem atingir. Pensando nisso, repetimos o processo de investigação no Google Trends e verificamos que o termo “depressão na quarentena” não apresentava interesse da população Brasileira entre janeiro e início de março (0 na escala) – esse desinteresse deve-se, provavelmente, ao fato de que ainda não existia o confinamento social no Brasil. Porém, a partir de março, a busca pelo termo cresceu muito, atingindo o pico de pesquisa (100 na escala) no início do mês de maio. Quando pesquisado, em Inglês, o termo “quarentine depression” também não houve interesse pela população mundial entre os meses de janeiro até o início de março. A partir daí, iniciou-se um aumento exponencial pela procura do termo, atingindo seu pico no mês de abril e, após, uma sequente diminuição até o mês de junho. Do espaço ao COVID-19: o que podemos aprender? Astronautas devem saber lidar com o confinamento e, apesar de serem submetidos a diversos tipos de treinamento para cumprir de forma adequada as missões espaciais, efeitos psicológicos provocados pelo confinamento são relatados na literatura. No caso da COVID-19, não houve preparo para essa nova realidade. Estamos todos tentando desenvolver mecanismos para desenvolver resiliência e melhor lidarmos com a pandemia e todos os acontecimentos relacionados à ela. A internet torna-se uma aliada, uma companhia provedora de informações e possibilidades de compras para as pessoas. O desafio agora é lidar com essa quantidade de informações, separando-as em relação à veracidade e à aplicabilidade. 
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Authors: Beatriz Helena Ramos Reis*, Bruno Veiga Fontes de Carvalho*, Prof Jonas Lírio Gurgel**, Prof Flávia Porto**Institute of Physical Education and Sports, State University of Rio de Janeiro (UERJ)
 The COVID-19 pandemic has generated the need to employ social distancing measures to reduce the spread of the new coronavirus. However, negative effects on the physical and mental health of individuals have been noted, as the sudden change in routine has resulted in a new lifestyle for people, who are now spending their lives in confinement. Increased worries, anxiety, prolonged sadness and inactivity are some of the consequences caused or aggravated by isolation. Physical exercise continues to be recognised as an effective non-medication strategy that is useful for mitigating these effects, as it helps in the prevention and treatment of physical, metabolic and/or psychological diseases. However, measures taken to suspend and limit the use of establishments, such as gyms and sports clubs, to avoid people gathering together, have led to many people undertaking regular physical activities within the home. In this context, an interesting phenomenon has been seen on the internet, which is an increase in the search for information online. Google Trends, for example, is a resource reporting the most searched terms in different locations of the world and reveals the popularity of these terms on a scale of 0 to 100. It was possible from this to identify an increased search for information related to the consequences of the pandemic and the needs it has generated. It can be seen that in Brazil, prior to March 2020, searches for the term in Portuguese “exercício físico em casa” had low popularity (fluctuating between 0% and 25% on the scale of Google searches). The following month, after the beginning of social distancing within the country, the search for this term has varied between approximately 40% and 100% until the present day. When analysing the same term in English, it was seen that interest in this search varied between 0% and 25% in January 2020, whereas, from February until May of this year, searches rose to between 25% and 100%, before decreasing in June after several countries had relaxed their isolation rules. Analysis of this data evidenced a considerable increase in the popularity of the term during this period, demonstrating a greater interest in the subject by Internet users. These variations seem to be linked to the closing and opening of trade and other activities around the world.  It is also interesting to mention the need to adapt to performing exercise at home. Consequently, it was noticed that interest in the sports equipment needed to practice physical exercise at home also increased, being demonstrated by searches on Google. The search for the term in Portuguese "equipamentos para atividade física" in the first two months of 2020 was close to zero in interest levels; by March interest had increased a lot, reaching 100 in April. From a global perspective, the term “equipment for physical activity”, researched in the English language showed a peak of interest (100 on the scale) in February and less interest by the beginning of June (0 on the scale). As the pandemic is not yet under control, and indeed with the prediction of new waves of contagions and deaths, it is very likely that people's habits will really change as a way of adapting to the new reality. While recognising that people are in general resilient, it cannot be denied that psychological damage is evident, and it is often even difficult to understand and deal with the magnitude of the feelings that may arise. With this in mind, we repeated the research process on Google Trends with the term in Portuguese “depressão na quarentena”, and found little interest from the Brazilian population between January and early March (0 on the scale), probably due to the fact that social confinement did not exist in Brazil at that time. However, from March onwards, the search for the term grew a lot, reaching a peak in searches (100 on the scale) by the beginning of May. Similarly, when researching the term “quarantine depression” in English, there was little interest in the world population between the months of January until early March, with a subsequent exponential increase in searches for the term, reaching a peak in April, followed by a decrease until the month of June. From Space to COVID-19: what can we learn? Astronauts need to know how to deal with confinement and, despite being submitted to various forms of training to adequately meet the challenges of space missions, psychological effects caused by confinement have already been reported in the literature. In the case of COVID-19, there was no preparation for this new reality, leaving us all trying to develop mechanisms to become more resilient to and cope better with the pandemic and all the events related to it. The Internet has become an ally, a service that provides information and shopping possibilities for people. The challenge now is to deal well with this volume of information, dividing it up in terms of what is true and what is applicable.  Concordia Research Station, Antarctica Ever fancied spending some time in Antarctica? If so, take a look through the writings of Dr Stijn Thoolen, an ESA-sponsored medical doctor spending 12 months at the Concordia research station. His photos will either inspire you to go do it, or remind you of how desolate and EXTREMELY cold it is! Do take a look at Part 1, Part 2, and Part 3 of his blog series, talking about his time at the world's southernmost continent. Dr Stijn ThoolenMedical Research Doctor, Concordia Research Station, Antarctica
It is a beautiful summer day. There is even less wind than usual (with constant summer temperatures, almost always a blue sky and few weather changes, we are mainly concerned with wind), so I am not afraid to go outside in my t-shirt today. The sun reflecting off the snow is attacking me from all directions, and I will most probably burn, but I don’t care. It may be my only chance this year (and I imagine that in a few months I will look back on this day just like you must now look back at those days at the beach, or under the green trees, in the warm sun…). It is busy in front of the station. To the left, an empty rack is being carried away, to the right boxes are sorted, behind me a human chain is carrying them away into a container, and in front of me the green “Merlot” hoists the heaviest stuff. The chaos has something of a busy market on the village square (but then just a little different). Everyone is helping to organize those few 1000 kilos of food brought in by the overland traverse. It had arrived here yesterday, finally, after a day or ten on the ice. Huge logistics. You could say that all that food has arrived just in time, after that monstrous New Year’s Eve dinner two days ago (never seen so much food, not enjoyable anymore). But now that I see with my own eyes what is being stored in those containers and in the station, I am confident we won’t starve this winter.  Fuel, food, material, and most importantly: my personal 110 kilos of fun. In the summer period, the traverse travels up and down several times from the coast to Concordia, over the ice cap, to supply the station, and so that we can start our winter with peace of mind.  The traverse seen by the French Pleiades satellite at an altitude of 700 kilometers. It looks pretty fragile to me. Credits: CNES Summer feels like one big party. I have installed myself in the ESA lab by now, as well as within our DC16 crew, who are all still happy to participate in the biomedical research projects (the ESA lab is also a party). Every few days another plane comes in to deliver a new load of guests or equipment, and pick up old ones. Nobody lives here permanently (although some are almost considered part of the furniture after too many summer campaigns). We are all guests, and we are all working towards one common goal: knowledge.  Greetings from DC16 in summer spirits.. Credits: IPEV / PNRA - S. Guesnier.  Finally I am installed in the ESA lab. Now that the HOMAIR project also covers for the Dutch, there is no need to worry anymore. There are currently around 70 people here at Concordia, a beautiful collection of the most diverse backgrounds but with that same goal, and all of us equally idiot to think that Antarctica is interesting enough to leave the comfort of home for. Seismologists, carpenters, glaciologists, climatologists, electricians, mechanics, meteorologists, astronomers, plumbers, physicists, physicians, cooks, ICT specialists, a cleaner, and a station leader. It makes for a lively experience and ensures that there is plenty to discover besides writing blog posts.  Concordia from above. Laboratories and scientific instruments are dotted around the base outside. Credits: CNES Mary UpritchardCo-Founder, Admin Director, InnovaSpace In 1666, while self-isolating at his manor house in Woolsthorpe, Lincolnshire due to the Great Plague, Sir Isaac Newton proved, using a prism, that white light was actually formed of a composition of different colours.  Source: Wikipedia Centuries later, Barry Ressler (Founder, President & CEO of Star Associates Inc. & CEO of ISMC Inc.) was running a series of Monochromatic UV germicidal experiments when, by chance, he also created some fascinating colourful images. He placed a data DVD near a window covered by a shade during the exposures for the experiment he was conducting. On the top of the DVD, Ressler placed a prism and a quartz spacer. When the shade was opened, the angle of the rays of the sun onto the DVD surface reflected through the prism and quartz onto a wall, resulting in the astonishing creation of Image 1.  IMAGE 1 - courtesy of Barry Ressler When light moves from one medium to another, some rays reflect or bounce back within an object made of glass or a quartz-like material. This was clearly demonstrated by his experiment, which showed the behaviour of light as the rays bounced around the room to reveal the proper wavelength of different colours of light in the visible light spectrum. Ressler captured the beauty of these interesting images using a digital 16MP Hasselblad "V" system with 50mm lens. The pictures also showed another interesting property of the quartz, as it can make one side of the object look like a mirror.  Image 2 - courtesy of Barry Ressler This is seen in Image 2, in which the red at the top of the quartz appears because of this mirror effect, reflecting the red from the base off the top of the quartz, while also refracting or bending the light to create the curved shape that can be seen. And Image 3 is such a thing of beauty, where you can almost pick out all of the colours of the visible spectrum of light, which have been memorised in the correct order by school children of many generations, using the well-known mnemonic – ROYGBIV – for example, richard-of-york-gave-battle-in-vain, signifying the colours in order: red, orange, yellow, green, blue, indigo, violet.  Image 3 - courtesy of Barry Ressler Barry Ressler confessed though that the images happened completely by chance, as he placed the prism and quartz spacer inadvertently on top of the data DVD.  The first medical x-ray, the hand of Roenrgen's wife Anna Bertha Ludwig, A fortunate case of serendipity that led to some stunning photos, and a not uncommon happening in the world of invention and discovery, whereby a little ‘luck’ or an ‘accident’ has led to an addition to the scientific knowledge. Just imagine if Dr Wilhelm Roentgen, Professor of Physics in Wurzburg, Bavaria, had not ‘accidently’ discovered X-rays while testing whether cathode rays could pass through glass! The first X-ray image ever was of his wife's hand, complete with ring, and his invention led him to become the first ever winner of the Nobel Prize in Physics in 1901.
The three prism and light images used in this blog, with the kind permission of Barry Ressler, first appeared and remain to this day on the American Physical Society Site - Physics Central, where the photos have met with a good deal of interest.
Welcome to Part 2 of the blog by Dr Stijn Thoolen, an ESA-sponsored medical doctor spending 12 months at Concordia research station in Antarctica. He facilitates a number of experiments on the effects of isolation, light deprivation, and extreme temperatures on the human body and mind.
Dr Stijn ThoolenMedical Research Doctor, Concordia Research Station, Antarctica November 8, 2019, somewhere above Asia I started early today, at 05:00 AM. Despite my sleep deprivation from a too long Nintendo farewell, I now jumped out of my friend’s bed without struggles. I give him, still half asleep, a last hug, and while I walk out of the door that radio in my head spontaneously starts playing again:
 Liftoff! With 6 flights I figured to put on my compression socks… Credit: S. Thoolen
Today it the day, finally. There have been few days in the past months where Concordia didn’t cross my mind. Enough thinking, enough talking, weeks of preparation and training, deadline after deadline finished: now it is time to make it happen! From Amsterdam to Paris, Hong Kong, Melbourne, Christchurch, and then off to the Antarctic, via the Italian coastal station Mario Zuccheli to our icy Dome C. It is only six flights and a day or five. What a party, and that fun is only further enhanced by all those happily-surprised faces of airport staff to whom I have to show my travel plans today (“Oh wow! Best of luck!”).
Today I am focused, bouncing from airport to airport full of curiosity, but the past few days were quite different. I have been ready for Concordia since the end of my training period early October, but over the past month more and more moments of realization squeezed through the goals and automatic pilot of my preparations, that I will really be away, for a full year, from about everything I see around me. Not that it bothered me much at first. It was quite funny actually (hah, Dutch gray rainy day, shall I miss you too?). But with my departure getting closer and the goodbyes less and less trivial, I was now getting overwhelmed with a feeling of uncertainty, a bit of fear perhaps, that I have not felt in years. So there I stood, sobbing and sniffling in my girlfriend’s arms at JFK airport in New York (you can imagine how awkward it is when at the same time a control-savoring security guard is screaming at you: “Sir, I need you to step out of the line, right now!”) InnovaSpace is pleased to welcome Dr Stijn Thoolen to tell us more about life at the Concordia Research Station in the Antarctic, an extreme environment where temperatures can fall below −80 °C (−112 °F) in the winter months. As an ESA-sponsored medical research doctor, Stijn will remain at the Franco-Italian research station for 13 months - definitely not an activity for the faint hearted! Dr Stijn ThoolenMedical Research Doctor, Concordia Research Station, Antarctica  Location of Concordia Research Station. Credits: ESA 75 ° 05’59 “S; 123 ° 19’56” E. I will spend 13 months of my life at these coordinates from November onwards. Far away from my girlfriend, my family and friends, from everything that I know and have loved for the past 28 years. A small 1700 km away from the South Pole, situated on a 3270-high ice sheet, with 40% less oxygen than at sea level (the atmosphere is thinner at the poles), a humidity lower than in the Sahara, average temperatures of –30°C in summer and –65°C in winter, four months without any ray of sunshine (is this lunchtime, or should I go to bed already?) and without possibility of evacuation for nine months, the Franco-Italian research station Concordia on Dome C in Antarctica sounds more like a base on another planet. Every year the European Space Agency sends a ‘hivernaut’ (a winter version of an astronaut?) to this abandoned outpost at the bottom of our globe to perform biomedical experiments on the crew, in preparation for missions to the Moon, Mars and who knows what’s next. This year it’s my turn, and those 13 months are starting to get awfully close… I hear you ask: why (…would you do that for God’s sake)? “In our history it was some horde of furry little mammals who hid from the dinosaurs, colonized the treetops and later scampered down to domesticate fire, invent writing, construct observatories and launch space vehicles” – Carl Sagan  ‘White Mars’, ‘planet Concordia’, you name it. Credits: ESA I sometimes ask myself that question as well, but you can imagine that the answer is as obvious as the undertaking itself.
Maybe we should start with a short self-evaluation: Self-evaluation is not something we often do. At least, I was never good at it. When everything goes according to plan, and everyone around you screams how wonderful it is that “little Stijn wants to become a surgeon!”, you aren’t really encouraged to take a critical look at yourself, right? But sometimes a shock (or two) helps to adjust a bit. A lesson in humility perhaps. For me, that first shock came about five years ago. I had said “yes” a little too much, a good friend died, my parents divorced, and with about ten suitcases of mental luggage I left for a research internship in Boston, USA, during my medical studies. In such a new environment, full with material to reflect on, things became a little more relative. I realised that nothing is as obvious as it seems, that some things might actually be bigger than us (the Universe, God, the flying spaghetti monster, you choose), and, even better, how beautiful and special it is that we are able to witness all that (I know this sounds dull, but I dare you to try with your eyes fixed on a bright, starry sky). Rosemary S. A. Shinkai, DDS, MSc, PhD Professor of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Brazil
We still do not know much about the changes in dental and orofacial structures, functions, and diseases beyond Earth. Early studies on aerospace dentistry published at the end of the 1960’s and 1970’s addressed some concerns about oral health in astronauts and challenges for dental treatment delivery in space. If astronauts are selected for being the most prepared and healthy humans to withstand the hard conditions in outer space, what about everyday regular people, the very young or old individuals? Or pregnant space voyagers? Microgravity and radiation in long-term spaceflights and a lifelong stay in space stations or settlements would require specific oral health care. Teeth, gums, tongue, bones, and muscles are part of a complex system, which is highly innervated and irrigated by blood vessels to allow chewing, swallowing, speaking, and smiling. Saliva is produced by a number of large and small salivary glands to lubricate the mouth, form the food bolus, and counterbalance acids produced by mouth bacteria after meals. Recent studies have shown that the microgravity and spaceflight environment alters jaw bone physiology, dental development, saliva proteins, and salivary gland morphology in mice flown on a US shuttle and a Russian biosatellite. Another study revealed that adult rats submitted to gravity tests showed remodeling of craniomandibular bones. Simulated microgravity also modified gene expression and physiology of Streptoccocus mutans and Streptoccocus sanguinis, possibly altering the cariogenic potential of these bacteria. However, the specific effect of space radiation also needs to be investigated.  Will oral health care need adapting for long-term Mars settlement? It still is unknown to what extent the same effect would occur in human astronauts. Besides the potential structural and physiological changes in the craniomandibular system, other behavioral factors and epigenetics are involved in space oral health. For example, dental caries result from a frequent exposure to acids produced by mouth bacteria after ingestion of sugar, mainly sticky or soft, paste-like foods. Thus, eating and cleaning habits modify the risk for dental caries. And the protective saliva flow and composition vary with water drinking, chewing stimulation, medication, and stress. All these factors may be altered in space life and would affect individual responses to not only dental caries risk, but also gum inflammation, orofacial pain, bone loss and repair. Understanding the underlying mechanisms to prevent oral health problems and have effective interventions seems to be appropriate for the planning of long-term space travel.
So, space dentistry may be an interesting job in the future! Prof. K. Ganapathy InnovaSpace Advisory Board member, Past President Telemedicine Society of India, Former Secretary/Past President Neurological Society of India & Indian Society for Stereotactic & Functional Neurosurgery, Emeritus Professor Tamilnadu Dr MGR Medical University, Former Adjunct Professor IIT Madras & Anna University Madras, Founder Director, Apollo Telemedicine Networking Foundation & Apollo Tele Health.  Three decades ago even contemplating the subject of the human brain in space would have been considered preposterous. Two decades hence and Extra Terrestrial Neurosciences could become a distinct sub-speciality. With periods of stay in the International Space Station steadily increasing, manned missions to the Moon being revived, and even humans going to Mars being seriously planned, it is imperative we know what happens structurally and functionally to various parts of the human brain when it is exposed to microgravity and cosmic radiation for prolonged periods. This is no longer a theoretical academic discussion. For decades we have relied on experimental simulation studies on the brains of rats exposed to microgravity and cosmic radiation. Mice exposed for six months to the radiation levels prevalent in interplanetary space exhibited serious memory and learning impairments, also becoming more anxious and fearful. Structural changes at a microscopic level, including changes in neurotransmitters were demonstrated.  It is only in the last decade that reliable, prospective clinical and sophisticated imaging studies have been carried out on astronaut brains before and after exposure to real world conditions. The human brain was primarily designed for standing in gravity on Earth with almost no exposure to radiation. When we leave the Earth’s gravitational pull all bodily fluids move upward. The first evidence for structural changes in the brain after long-term spaceflight includes narrowing of the central sulcus, a shrinking of the cerebrospinal fluid (CSF) spaces at the vertex, and an upward shift of the brain. MRI scans before spaceflight, shortly after and several months after return to Earth revealed a significant increase in size of the lateral and third ventricles immediately post-flight and a trend towards normalization at follow-up. There was an upward shift of the brain after all long-duration flights. Significant volumetric gray matter decreases, including large areas in the temporal and frontal poles and around the orbits have been documented. This effect was more noticeable in crewmembers with prolonged stay in the International Space Station. Bilateral focal gray matter increases within the medial primary somatosensory and motor cortex (cerebral areas representing lower limbs) were noted. Cortical reorganization in an astronaut’s brain after long-duration spaceflight has now been confirmed. MRI documented structural changes raise the risk of possible impairment of behaviour, cognition and performance. This could compromise mission critical decisions. In 2017, a study revealed that long missions in space results in reduction of protective CSF surrounding brain volume at the top of astronauts’ brains. These changes underlie the astronauts’ performance on certain critical tasks, such as opening the space station’s hatch, climbing a ladder, exiting a vehicle or even walking along the surface of a planet. Follow up MRI scans have revealed that re-exposure to Earth’s gravity and lack of continuing exposure to unnatural radiation can generally reverse these space travel induced changes. Astronauts have to undergo extensive training before and during spaceflight to maintain muscle mass, and this can result in localised increased grey matter, particularly in the sensorimotor regions of the brain, representing the lower limbs. This is due to neuroplasticity or adaptation within the cerebrum and cerebellum. The most notable findings in the MRI’s were a post-flight increase in the stimulation-specific connectivity of the right posterior supra marginal gyrus with the rest of the brain; a strengthening of connections between the left and right insulae, decreased connectivity of the vestibular nuclei, right inferior parietal cortex and cerebellum with areas associated with motor, visual, vestibular, and proprioception functions. Study of permanent visual acuity impairments associated with spaceflight have demonstrated structural changes in the CSF around the optic nerves and the globe of the eyes.
Domain expertise in Extra Terrestrial Neurosciences will eventually be a reality. While the number of subjects studied may at the best be a few hundreds, the lessons learnt could make us relook at the traditional neurosciences we have been believing in for the last two centuries. Let us never forget that the future is always ahead of schedule !! Fabrício Edler Macagnan PhDAssistant Professor, Dept of Physical Therapy, Graduate Program in Rehabilitation Sciences Can technology really be seen as something unnatural? Or is it plausible to assume that all the evolutionary processes developed on our planet have been truly responsible for our ability to promote evolution (transformation) in a fully conscious and directed manner? Well, if this is true, then we can say that “all technology is eminently a natural manifestation of the evolutionary process.”  In the ongoing developmental process, how many different random combinations were needed to enable the evolution of simple inorganic compounds into extremely complex living organisms, capable of interpreting, acting and reacting to environmental events? In the animal kingdom, we find numerous individual and collective actions that occur to ensure the preservation of species. Each of these strategies have been tested for efficiency by the process of natural selection, and from this perspective it can be said that the validation of a viable adaptation represents a natural manifestation of biotechnological development. These acts of biotechnological development range from behavioural patterns that are beneficial for preservation of the most adapted genes and, consequently, more prone to reproductive success, through to defence techniques using chemical substances capable of triggering complex and fatal metabolic reactions in opponents (to this day, the pharmaceutical industry maintain strong interest in these biotechnologies). There are numerous evolutionary strategies that could be described, but in short, each of these adaptations (strategies) could be framed under the concept of technology, as technology involves the systematic study of techniques, processes, methods, means and instruments that are used to achieve a determined goal. The great difference between the processes occurring at the beginning of species evolution and those that now occur is really the most remarkable fact of all development – the ability to become aware of certain processes of existence (life). Whenever I stop to think about it, I’m extremely curious to know at what point in evolution did the ability emerge of being able to connect information from different body movement receptors (sensors) in a sufficiently organised way to permit repetition (from a sequence of carefully and efficiently stored historical events) of the intensity, direction, and reaction of forces acting on moving bodies to the point of making interpretation and reaction intentionally directed for one's own benefit. This intricate capacity for historical analysis has enabled numerous evolutionary advances in species, which have since developed techniques for collecting, hunting, fighting and defending, whether individually or collectively, with such efficiency that survival in ensured, even in the face of drastic environmental transformations. Even more noticeable has been the developments in language and writing, a crucial step for storing and sharing huge volumes of information, which has accelerated the creation of useful techniques for dealing with questions involving mathematics, physics, chemistry, biology, astronomy, etc. Moreover, even after conquering land, sea and sky, all known sciences have undeniably been heavily affected by the computational advances in data processing and sharing (internet). Humankind has greatly enlarged knowledge of many natural events and even ventured into Space, but without a doubt, something that is truly spectacular is the surprising discovery of the nano-microscopic features that enable us to edit (manipulate) portions of our genetic library, a place where information has been perpetuated over eons. Future prospects for the use of gene editing in the scientific scenario remains unclear, but the possibility of acting intentionally at a molecular level may effectively contribute to a reduction in the need to treat disease and guarantee a new step in the evolutionary scale, in which our focus shifts to the promotion of health improvement and living conditions.  For a long time the natural selection of best strategies has been restricted to the field of spontaneous randomness, but we have now developed rigorously designed laboratory assessments to test hypotheses, which are validated through a specific set of statistical rules that increasingly allow us to project the future probability of success or failure of a given action. With new computational advances (Internet of Things and quantum processors) we will further accelerate the progress of technological development. There is, however, no point in so much technology if we maintain prehistoric attitudes that dominate behavioural rules. For example, greed, which was once so necessary for survival, is one such behaviour that, in my view, should have long since fallen into disuse, together with violence and war. An existence of peace and harmony is more than feasible. We have a huge arsenal of knowledge to ensure a much healthier future for all living beings on our planet - we just need to want it enough! I sincerely hope we have the wisdom needed to make good ethical and legal choices that lead us along a successful path for all.
Author: Adriana Bos-Mikich PhDDepartment of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Brazil  The last few decades have seen remarkable progress in our ability to safely launch manned craft into the black abyss of space, boosted in recent years by the growing involvement of commercial space enterprise, such as SpaceX and Blue Origin. With it has come a rising desire to work towards the establishment of longer-term human settlements in orbiting space stations and on the Moon and Mars. Recent experiments, although methodologically limited, have demonstrated that frozen human sperm samples are not affected by the microgravity conditions encountered in spaceflight, which is an important and positive finding. However, life in space is not confronted by microgravity alone, but is also faced with high radiation levels, which may well represent a relevant source of concern when dealing with human reproduction beyond Earth. Cryopreserved sperm and oocyte samples stored in outer space under these two hostile conditions must survive and maintain viability long enough to generate viable embryos, if they are eventually to result in healthy babies born aboard space stations. The putative effects of long-term storage of human gametes and embryos under Earth atmospheric conditions have already been investigated. Data from early clinical and experimental studies have shown that background radiation has no deleterious impact on babies created after long-term storage of frozen human embryos and oocytes. Therefore, the next steps should involve similar experiments taking place under the conditions of being in an outer space environment, where radiation levels are far higher than on Earth, before considering the generation of embryos using cryopreserved gametes stored on space stations. Nonetheless, the risks of reduced viability due to radiation levels and microgravity are not the only concerns related to the cryostorage and shipment of human gametes. There are other risks associated with the cryostorage of biological material, both on Earth and in Space, ranging from the transmission of diseases between samples stored in liquid nitrogen, to unintentional loss due accidental warming. The loss of oocytes and embryos due to major equipment failure has been reported in fertility clinics, with thousands of gametes and embryos being lost worldwide. As reported by assisted reproduction specialist Dr Mina Alikani in 2018, the maintenance of a very low temperature and avoidance of temperature fluctuations are key factors for the safe and long-term cryostorage of human cells and tissues. Additionally, the shipment and handling of cryopreserved biological samples represents another potential hazard for gametes and embryos. Results of research by Casey McDonald and colleagues in 2011, using donated human oocytes, warned of the effects of the ‘inherent perils of shipping’ on the lowering of survival rates, with exposure to elevated ambient temperature and air pressure, vibration or any other physical shock potentially contributing to poorer results.  Therefore, for the successful transport of biological samples under cryostorage, it is essential that appropriate shipping vessels be used, such as those allowing continuous temperature monitoring, rather than relying on data collected at the final destination.
Big question marks remain as to whether healthy babies can be born following the use of in vitro fertilization technologies performed in outer space. Furthermore, major safety and ethical concerns must be taken into consideration before such a giant leap for humanity is taken. See also article: Assisted reproduction frontiers in outer space |
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