Prof. K. GanapathyInnovaSpace Advisory Board member, Past President Telemedicine Society of India, Former Secretary/Past President Neurological Society of India & Indian Society for Stereotactic & Functional Neurosurgery, Emeritus Professor Tamilnadu Dr MGR Medical University, Former Adjunct Professor IIT Madras & Anna University Madras, Founder Director, Apollo Telemedicine Networking Foundation & Apollo Tele Health. Could Telehealth be the way forward in helping to manage the COVID-19 pandemic in India? The InnovaSpace Team
Quando se pensa em viajar de avião, a primeira coisa que vem à cabeça é o serviço de bordo e as opções de alimentação. Brincadeira! É a segurança, claro. Todo mundo quer decolar, viajar e aterrissar em paz. Mas, para que tudo possa acontecer de uma forma tão profissional que você nem perceba, muitas pessoas estão trabalhando nos bastidores. A tripulação – piloto, copiloto, comissários, técnicos – tem muita responsabilidade. Vivem uma rotina difícil de horas e horas no ar, com alguns intervalos no solo. Por isso, você já imaginou como é a saúde deles? Como fazem para ter corpo e mente saudáveis? E os passageiros? Será que todos estão em condições de voar? Esses questionamentos motivaram horas de estudo dos médicos Thais Russomano e João de Carvalho Castro, os quais dedicaram muito de sua vida acadêmica à medicina aeroespacial. E você tem a oportunidade de conhecer o trabalho deles em detalhes através do eBook "A Fisiologia Humana no Ambiente Aeroespacial".  Abaixo, um trecho do livro para que você possa se inspirar: "O sonho de voar sempre esteve presente no imaginário humano desde os tempos mais remotos. Atualmente, cruzar o mundo de um lado para o outro, aproximando pessoas, vencendo barreiras geográficas e integrando culturas, é uma realidade viável e acessível. O ambiente aeroespacial, porém, difere do terrestre e impõe vários riscos à saúde e à segurança de aviadores, da tripulação de bordo e de passageiros durante um voo." O eBook foi oficialmente lançado em 19 de Fev, na Ordem dos Médicos, Secção Sul, Lisboa, Portugal, com o suporte da Sociedade Médica Científica Aeroespacial - Associação Portuguesa (SMAPor). Os convidados tiveram ainda a oportunidade de assistir a três palestras. Na primeira, Thais Russomano debateu o tema "Fisiologia Humana no Espaço". Após, João Castro explorou aspectos ligados à "Fisiologia Aeroespacial". Por fim, a médica Rosirene Gessinger abordou o tema "Medicina de Aviação". O evento e o eBook são iniciativas da InnovaSpace, uma empresa britânica do tipo Think Tank, global e inclusiva, de caráter multicultural e multidisciplinar. A InnovaSpace atua nas áreas espacial, aeronáutica e em telessaúde. E tem uma missão educativa muito importante: fazer com que a ciência espacial seja democratizada, tornando-a um assunto comum ao maior número possível de pessoas mundo afora!
O livro pode ser comprado no site Smashwords. Registre-se aqui primeiro, faça uma pesquisa usando nome dos autores ou o título do livro para encontrá-lo. Compre e faça o download, como um arquivo epub ou mobi. Rosemary S. A. Shinkai, DDS, MSc, PhD Professor of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Brazil
We still do not know much about the changes in dental and orofacial structures, functions, and diseases beyond Earth. Early studies on aerospace dentistry published at the end of the 1960’s and 1970’s addressed some concerns about oral health in astronauts and challenges for dental treatment delivery in space. If astronauts are selected for being the most prepared and healthy humans to withstand the hard conditions in outer space, what about everyday regular people, the very young or old individuals? Or pregnant space voyagers? Microgravity and radiation in long-term spaceflights and a lifelong stay in space stations or settlements would require specific oral health care. Teeth, gums, tongue, bones, and muscles are part of a complex system, which is highly innervated and irrigated by blood vessels to allow chewing, swallowing, speaking, and smiling. Saliva is produced by a number of large and small salivary glands to lubricate the mouth, form the food bolus, and counterbalance acids produced by mouth bacteria after meals. Recent studies have shown that the microgravity and spaceflight environment alters jaw bone physiology, dental development, saliva proteins, and salivary gland morphology in mice flown on a US shuttle and a Russian biosatellite. Another study revealed that adult rats submitted to gravity tests showed remodeling of craniomandibular bones. Simulated microgravity also modified gene expression and physiology of Streptoccocus mutans and Streptoccocus sanguinis, possibly altering the cariogenic potential of these bacteria. However, the specific effect of space radiation also needs to be investigated.  Will oral health care need adapting for long-term Mars settlement? It still is unknown to what extent the same effect would occur in human astronauts. Besides the potential structural and physiological changes in the craniomandibular system, other behavioral factors and epigenetics are involved in space oral health. For example, dental caries result from a frequent exposure to acids produced by mouth bacteria after ingestion of sugar, mainly sticky or soft, paste-like foods. Thus, eating and cleaning habits modify the risk for dental caries. And the protective saliva flow and composition vary with water drinking, chewing stimulation, medication, and stress. All these factors may be altered in space life and would affect individual responses to not only dental caries risk, but also gum inflammation, orofacial pain, bone loss and repair. Understanding the underlying mechanisms to prevent oral health problems and have effective interventions seems to be appropriate for the planning of long-term space travel.
So, space dentistry may be an interesting job in the future! Prof. K GanapathyInnovaSpace Advisory Board member, Past President Telemedicine Society of India, Former Secretary/Past President Neurological Society of India & Indian Society for Stereotactic & Functional Neurosurgery, Emeritus Professor Tamilnadu Dr MGR Medical University, Former Adjunct Professor IIT Madras & Anna University Madras, Founder Director, Apollo Telemedicine Networking Foundation & Apollo Tele Health.  January 22-24th 2020 saw the taking place of an international Symposium on Human Spaceflight, in Bengaluru, India. The event, jointly organised by the Indian Space Research Organisation (ISRO), International Academy of Astronautics (IAA) and Astronautical Society of India (ASI), under the theme of ‘Human Space Flight and Exploration – Present Challenges and Future Trends’, saw the coming together of more than 500 national and international delegates, all experts in the field of human spaceflight related technologies, from space agencies, astronauts, representatives of International space industries and academic institutes, young professionals and students. The Symposium was inaugurated on the 22nd January 2020 by Prof. K VijayRaghavan, Principal Scientific Advisor to the Government of India, in the presence of Dr K Sivan, Chairman of ISRO, and the Honourable Prime Minister of India, Shri Narendra Modi conveyed a special message to the symposium participants. The PM highlighted that the benefits of India’s Space programme should be shared with the entire world, in line with India’s wisdom of "Vasudaiva Kutumbakam" - which in Sanskrit means the World is one family. Shri P Kunhikrishnan, Director, URSC and Chairman of the Local Organising Committee, welcomed the participants. Dr B N Suresh, Honorary Distinguished Professor, ISRO and Dr Jean Marc Astorg, Director Launch Vehicle Directorate, CNES, France, the International Programme Committee Co-Chairs addressed the gathering.  Symposium participants and delegates Image source: ISRO The ‘Heads of Space Agencies Panel’ was composed of the Space Agency chiefs from India and Romania, and the heads of the Human Spaceflight Programmes of CNES (France), NASA (USA), JAXA (Japan), ASI (Italy), and ROSCOSMOS (Russia). The agency heads made deliberations on the progress and future plans of the respective Space Agencies under the changing landscape and economics of human spaceflight and deep space exploration. Mr Jean-Yves Le Gall, President of CNES addressed the gathering on January 24, 2020 on the Indo–French partnership in human spaceflight. Another significant event in the Symposium was the ‘Astronaut Panel’ held on January 23, 2020 with the participation of five astronauts from France, Germany, Russia, USA and UAE, with the panel being moderated by Air Commodore (Retd) Mr Ravish Malhotra. The astronauts presented their thoughts on spaceflight and the technical, physiological and psychological challenges of humans during spaceflight.  Prof K Ganapathy at the Symposium The Symposium received a good response from the Industry, and an exclusive industry panel was also organised providing an opportunity for Indian and foreign space industry leaders to discuss their perspectives on human spaceflight and exploration. A total of 19 invited and plenary lectures were delivered by eminent experts in the Human spaceflight area, from USA, Russia, France, Japan, Italy, Germany and the UAE. Around 100 technical papers were presented by the delegates from different countries under 5 major topics, namely, Challenges, Enabling Technologies, Ground Systems, Scientific and Societal Relevance, Policy Aspects and Economics of human spaceflight. In addition, an exclusive student session was held (January 23, 2020) to give a special focus on the younger generation. Sixty students from premium academic institutions across the country participated in the session and 10 selected papers were presented by students. An exhibition of technologies and products related to Human Spaceflight, including space food, was organised as part of the symposium. A full-size model of a Crew Module, scaled models of the Crew Escape System, and the space station concept were showcased. The three-day Symposium has enabled an exchange of information between the delegates on the latest trends in human spaceflight exploration.  India's Vyommitra 'space robot' Also on show at the symposium was the Vyommitra 'space robot', a half-humanoid being made to accompany astronauts on the #Gaganyaan mission, and able to monitor biological parameters and perform life support operations. The robot will also be able to converse with the astronauts, recognise them and respond to their queries, as well as respond to commands from the control centre in Bengaluru and give feedback to the scientists who will be monitoring from Earth. Sources: 1 - https://www.isro.gov.in/update/24-jan-2020/iaa-isro-asi-symposium-human-space-flight-and-exploration-was-organised-bangalore 2 - https://www.news18.com/news/tech/isros-vyom-mitra-humanoid-robot-set-for-an-unmanned-trip-into-space-watch-video-2469801.html InnovaSpace Advisory Board Member Prof K. Ganapathy presented a paper at the symposium on “Neurological Changes in Outer Space”. It was the only paper presented by a medical doctor and served to raise the awareness of leading space scientists, engineers and technologists to the significance of giving equal importance to the health of the Vyomanauts on board the spacecraft.
Nikolaos Divinis BEng (Hons), MSc, PhDAerospace Engineer, Founder of EN School of Unity,  The ‘’black hole’’ is really one of the most mysterious celestial objects. Some people, indeed, claim that the laws of physics do not exist in its interior. A ‘’black hole’’ is that point in space where the core of a gigantic star used to be. It is a sphere of matter and not a material vacuum. Whatever ‘’falls’’ inside it ‘’gets lost’’ from the universe, because gravity here is so strong that even the light cannot escape from its tractive force. So, the term ‘’black hole’’ is used in this sense. ‘’Hole’’, because an object like this absorbs like a ‘’spacial whirlpool’’ anything that crosses its path, and ‘’black’’, because not even the light can escape from its ‘’surface’’ so as to be recorded by our eyes or by the various sensitive instruments of our observatories. It is a ‘’star’’ which has collapsed into an infinitesimally tiny size, leaving behind only the intensity of its gravity. Human beings need to go through a black hole in order to return to the original organism. Humans need to become healthy in order to ‘’rise’’. Not even the light can go through, as it does not express the complete sense of light that is diffused in the Universe, but it is only expressed as photon. A state of light of inferior quality. The black hole represents both symbolically and literally the condition which isolates our Universe, our galaxy from the sound concepts of the Universe. It is also, both in symbolic and literal terms, the gate through which someone can go to that side.  To go through this gate, someone should understand the concept of love, which is the only concept that can be expressed to the full extent in our world, in modern civilisation, because it is the sole compass/lodestar that will lead us to the bliss of our existence as we take pleasure in the gift of this life, and later of the next.
Excerpt From a book by Nikolaos Divinis. “Humans, A conceptual approach to existence.” Daidaleos Publications, iBooks, Amazon Prof. K. Ganapathy InnovaSpace Advisory Board member, Past President Telemedicine Society of India, Former Secretary/Past President Neurological Society of India & Indian Society for Stereotactic & Functional Neurosurgery, Emeritus Professor Tamilnadu Dr MGR Medical University, Former Adjunct Professor IIT Madras & Anna University Madras, Founder Director, Apollo Telemedicine Networking Foundation & Apollo Tele Health.  Three decades ago even contemplating the subject of the human brain in space would have been considered preposterous. Two decades hence and Extra Terrestrial Neurosciences could become a distinct sub-speciality. With periods of stay in the International Space Station steadily increasing, manned missions to the Moon being revived, and even humans going to Mars being seriously planned, it is imperative we know what happens structurally and functionally to various parts of the human brain when it is exposed to microgravity and cosmic radiation for prolonged periods. This is no longer a theoretical academic discussion. For decades we have relied on experimental simulation studies on the brains of rats exposed to microgravity and cosmic radiation. Mice exposed for six months to the radiation levels prevalent in interplanetary space exhibited serious memory and learning impairments, also becoming more anxious and fearful. Structural changes at a microscopic level, including changes in neurotransmitters were demonstrated.  It is only in the last decade that reliable, prospective clinical and sophisticated imaging studies have been carried out on astronaut brains before and after exposure to real world conditions. The human brain was primarily designed for standing in gravity on Earth with almost no exposure to radiation. When we leave the Earth’s gravitational pull all bodily fluids move upward. The first evidence for structural changes in the brain after long-term spaceflight includes narrowing of the central sulcus, a shrinking of the cerebrospinal fluid (CSF) spaces at the vertex, and an upward shift of the brain. MRI scans before spaceflight, shortly after and several months after return to Earth revealed a significant increase in size of the lateral and third ventricles immediately post-flight and a trend towards normalization at follow-up. There was an upward shift of the brain after all long-duration flights. Significant volumetric gray matter decreases, including large areas in the temporal and frontal poles and around the orbits have been documented. This effect was more noticeable in crewmembers with prolonged stay in the International Space Station. Bilateral focal gray matter increases within the medial primary somatosensory and motor cortex (cerebral areas representing lower limbs) were noted. Cortical reorganization in an astronaut’s brain after long-duration spaceflight has now been confirmed. MRI documented structural changes raise the risk of possible impairment of behaviour, cognition and performance. This could compromise mission critical decisions. In 2017, a study revealed that long missions in space results in reduction of protective CSF surrounding brain volume at the top of astronauts’ brains. These changes underlie the astronauts’ performance on certain critical tasks, such as opening the space station’s hatch, climbing a ladder, exiting a vehicle or even walking along the surface of a planet. Follow up MRI scans have revealed that re-exposure to Earth’s gravity and lack of continuing exposure to unnatural radiation can generally reverse these space travel induced changes. Astronauts have to undergo extensive training before and during spaceflight to maintain muscle mass, and this can result in localised increased grey matter, particularly in the sensorimotor regions of the brain, representing the lower limbs. This is due to neuroplasticity or adaptation within the cerebrum and cerebellum. The most notable findings in the MRI’s were a post-flight increase in the stimulation-specific connectivity of the right posterior supra marginal gyrus with the rest of the brain; a strengthening of connections between the left and right insulae, decreased connectivity of the vestibular nuclei, right inferior parietal cortex and cerebellum with areas associated with motor, visual, vestibular, and proprioception functions. Study of permanent visual acuity impairments associated with spaceflight have demonstrated structural changes in the CSF around the optic nerves and the globe of the eyes.
Domain expertise in Extra Terrestrial Neurosciences will eventually be a reality. While the number of subjects studied may at the best be a few hundreds, the lessons learnt could make us relook at the traditional neurosciences we have been believing in for the last two centuries. Let us never forget that the future is always ahead of schedule !! The InnovaSpace TeamThe person who will first set foot on Mars is already born... How is it possible to keep in touch with family while on Mars? Have you ever thought about this? This very important question was asked by Vincenzo, aged 13, from Italy, who participated in the InnovaSpace Kids2Mars project. The answer is simple: you will be able to send emails and photos direct from Mars, but you'll have to be patient, as the messages will take about 10 minutes to reach Earth because of the distance. It's very far as you know. Who explained this to Vincenzo was João Lousada, an analogue astronaut who participated in a Mars simulation mission in a Middle Eastern desert in the country of Oman. Lousada said that astronauts will need to keep in touch with their families, who are their main link to Earth. Like Vicenzo, 52 other children and adolescents participated in this project. They were able to ask questions of astronauts from two simulated Mars missions, one in Oman and the other in the Utah desert, in the USA. Girls and boys from 33 different countries asked smart and creative questions that can divided into 7 subject groups: 1) Martian environment & resources 2) Astronaut wellbeing 3) Equipment needed for Mars exploration 4) Interplanetary travel - from Earth to Mars 5) Mars habits 6) Astronaut selection & training 7) Animals, plants & food on Mars The Kids2Mars project is an initiative of InnovaSpace, an international institution created with the aim of making science more accessible. Children born in this century will witness a transformation in the history of humanity: the first mission to the Red Planet. The journey to Mars will be an event that marks our lives, just as the arrival of humans on the Moon in 1969 changed the lives of generations. And InnovaSpace wants to help young people to participate in this dream.  Como é possível manter contato com a família estando em Marte? Você já pensou sobre isso? Essa pergunta tão importante foi feita pelo Vincenzo, de 13 anos, que é da Itália e participa do projeto Kids2Mars, da InnovaSpace. A resposta é simples: direto de Marte, você vai poder mandar e-mail, fotos, mas tem que ter paciência, porque as mensagens vão demorar pelo menos 10 minutos para chegar à Terra por causa da distância. Quem explicou ao Vincenzo foi o astronauta João Lousada, que participou da simulação de uma viagem a Marte num deserto de Omã, no Oriente Médio. Lousada disse que os astronautas vão precisar ter contato com suas famílias, que são o principal vínculo deles com a Terra. Assim como Vicenzo, outras 52 crianças e adolescentes participaram desse projeto. Eles puderam fazer perguntas a astronautas de duas missões simuladas de viagem a Marte, uma em Omã e a outra no deserto do estado de Utah, nos Estados Unidos. Meninas e meninos de 33 países diferentes fizeram perguntas inteligentes e criativas que podem ser divididas em 7 grupos: 1) ambiente e recursos marcianos 2) bem-estar dos astronautas 3) equipamentos para visitar Marte 4) viagem interplanetária 5) hábitos em Marte 6) treinamento e seleção para astronauta 7) animais, plantas e comida em Marte As crianças nascidas neste século vão ser testemunhas de uma transformação na história da humanidade: a primeira missão ao planeta vermelho. Assim como em 1969 a chegada de seres humanos à Lua mudou a vida de gerações, a viagem a Marte será um acontecimento que vai marcar as nossas existências. E a InnovaSpace quer contribuir para que nossos jovens participem desse sonho. Nikolaos Divinis BEng(Hons), MSc, PhDAerospace Engineer, Founder of EN School of Unity,  The Big Bang has thus far been the prevailing cosmogonic theory, according to which, the Universe was created by an excessively dense and hot state, approximately 13.8 billion years ago. According to science, time and space did not exist before the Big Bang. Only the cosmic core existed, that original seed of limitless dimensions, which enclosed the germ of a whole universe. Everything started with the ''Big Bang''. Time zero is the moment of explosion, from which everything originates. In a storm of creation, subatomic particles collide with each other and are ejected. Photons change into matter, matter changes into energy, energy changes into matter. Every material particle we see around us originates from that first millisecond. And reaching today, when the visible Universe contains approximately 3 to 7x1022 stars, which are organised in approximately 8x1010 galaxies. The reason behind the Big Bang The objective of every element of the Universe is to express its superessential state. This can be reached only by experiencing to the fullest the unity with itself and with the other elements that are widespread in the universe. A human being who has reached this state is free from everything, with no pettiness, having no problems with fellow humans, is healthy and has all that is needed to lead their life, is blessed, which means imperishable, steadfast, immune and irreproachable. Can a human being experience unity during their life? The answer is yes, because it is something contained within, but it has simply been forgotten. It was acquired and then was lost. The heart leads towards that way, but the will is not strong enough to oppose the prescripts of human society. All it would take is the will and the way to unity would be paved. Here on Earth humans are experiencing the loss of unity and at this space-time moment, the universe is their guide. ALL the conditions of our life are synchronized with this in mind.  Everything started with the Big Bang. Scientists believe this was the beginning, but I would say, this was the end. The end of unity. And as the years go by, the elements increasingly move away from each other (the universe constantly expanding), in the same way human souls are moving away from the Source and from each other.
Science is led to conclusions through the experiment and observation, by means of analysis and not of synthesis. It interprets the findings through the limitations of the mind and through doubt, and not through the certainty that there is a wise cooperation behind everything. Fabrício Edler Macagnan PhDAssistant Professor, Dept of Physical Therapy, Graduate Program in Rehabilitation Sciences Can technology really be seen as something unnatural? Or is it plausible to assume that all the evolutionary processes developed on our planet have been truly responsible for our ability to promote evolution (transformation) in a fully conscious and directed manner? Well, if this is true, then we can say that “all technology is eminently a natural manifestation of the evolutionary process.”  In the ongoing developmental process, how many different random combinations were needed to enable the evolution of simple inorganic compounds into extremely complex living organisms, capable of interpreting, acting and reacting to environmental events? In the animal kingdom, we find numerous individual and collective actions that occur to ensure the preservation of species. Each of these strategies have been tested for efficiency by the process of natural selection, and from this perspective it can be said that the validation of a viable adaptation represents a natural manifestation of biotechnological development. These acts of biotechnological development range from behavioural patterns that are beneficial for preservation of the most adapted genes and, consequently, more prone to reproductive success, through to defence techniques using chemical substances capable of triggering complex and fatal metabolic reactions in opponents (to this day, the pharmaceutical industry maintain strong interest in these biotechnologies). There are numerous evolutionary strategies that could be described, but in short, each of these adaptations (strategies) could be framed under the concept of technology, as technology involves the systematic study of techniques, processes, methods, means and instruments that are used to achieve a determined goal. The great difference between the processes occurring at the beginning of species evolution and those that now occur is really the most remarkable fact of all development – the ability to become aware of certain processes of existence (life). Whenever I stop to think about it, I’m extremely curious to know at what point in evolution did the ability emerge of being able to connect information from different body movement receptors (sensors) in a sufficiently organised way to permit repetition (from a sequence of carefully and efficiently stored historical events) of the intensity, direction, and reaction of forces acting on moving bodies to the point of making interpretation and reaction intentionally directed for one's own benefit. This intricate capacity for historical analysis has enabled numerous evolutionary advances in species, which have since developed techniques for collecting, hunting, fighting and defending, whether individually or collectively, with such efficiency that survival in ensured, even in the face of drastic environmental transformations. Even more noticeable has been the developments in language and writing, a crucial step for storing and sharing huge volumes of information, which has accelerated the creation of useful techniques for dealing with questions involving mathematics, physics, chemistry, biology, astronomy, etc. Moreover, even after conquering land, sea and sky, all known sciences have undeniably been heavily affected by the computational advances in data processing and sharing (internet). Humankind has greatly enlarged knowledge of many natural events and even ventured into Space, but without a doubt, something that is truly spectacular is the surprising discovery of the nano-microscopic features that enable us to edit (manipulate) portions of our genetic library, a place where information has been perpetuated over eons. Future prospects for the use of gene editing in the scientific scenario remains unclear, but the possibility of acting intentionally at a molecular level may effectively contribute to a reduction in the need to treat disease and guarantee a new step in the evolutionary scale, in which our focus shifts to the promotion of health improvement and living conditions.  For a long time the natural selection of best strategies has been restricted to the field of spontaneous randomness, but we have now developed rigorously designed laboratory assessments to test hypotheses, which are validated through a specific set of statistical rules that increasingly allow us to project the future probability of success or failure of a given action. With new computational advances (Internet of Things and quantum processors) we will further accelerate the progress of technological development. There is, however, no point in so much technology if we maintain prehistoric attitudes that dominate behavioural rules. For example, greed, which was once so necessary for survival, is one such behaviour that, in my view, should have long since fallen into disuse, together with violence and war. An existence of peace and harmony is more than feasible. We have a huge arsenal of knowledge to ensure a much healthier future for all living beings on our planet - we just need to want it enough! I sincerely hope we have the wisdom needed to make good ethical and legal choices that lead us along a successful path for all.
Author: Adriana Bos-Mikich PhDDepartment of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Brazil  The last few decades have seen remarkable progress in our ability to safely launch manned craft into the black abyss of space, boosted in recent years by the growing involvement of commercial space enterprise, such as SpaceX and Blue Origin. With it has come a rising desire to work towards the establishment of longer-term human settlements in orbiting space stations and on the Moon and Mars. Recent experiments, although methodologically limited, have demonstrated that frozen human sperm samples are not affected by the microgravity conditions encountered in spaceflight, which is an important and positive finding. However, life in space is not confronted by microgravity alone, but is also faced with high radiation levels, which may well represent a relevant source of concern when dealing with human reproduction beyond Earth. Cryopreserved sperm and oocyte samples stored in outer space under these two hostile conditions must survive and maintain viability long enough to generate viable embryos, if they are eventually to result in healthy babies born aboard space stations. The putative effects of long-term storage of human gametes and embryos under Earth atmospheric conditions have already been investigated. Data from early clinical and experimental studies have shown that background radiation has no deleterious impact on babies created after long-term storage of frozen human embryos and oocytes. Therefore, the next steps should involve similar experiments taking place under the conditions of being in an outer space environment, where radiation levels are far higher than on Earth, before considering the generation of embryos using cryopreserved gametes stored on space stations. Nonetheless, the risks of reduced viability due to radiation levels and microgravity are not the only concerns related to the cryostorage and shipment of human gametes. There are other risks associated with the cryostorage of biological material, both on Earth and in Space, ranging from the transmission of diseases between samples stored in liquid nitrogen, to unintentional loss due accidental warming. The loss of oocytes and embryos due to major equipment failure has been reported in fertility clinics, with thousands of gametes and embryos being lost worldwide. As reported by assisted reproduction specialist Dr Mina Alikani in 2018, the maintenance of a very low temperature and avoidance of temperature fluctuations are key factors for the safe and long-term cryostorage of human cells and tissues. Additionally, the shipment and handling of cryopreserved biological samples represents another potential hazard for gametes and embryos. Results of research by Casey McDonald and colleagues in 2011, using donated human oocytes, warned of the effects of the ‘inherent perils of shipping’ on the lowering of survival rates, with exposure to elevated ambient temperature and air pressure, vibration or any other physical shock potentially contributing to poorer results.  Therefore, for the successful transport of biological samples under cryostorage, it is essential that appropriate shipping vessels be used, such as those allowing continuous temperature monitoring, rather than relying on data collected at the final destination.
Big question marks remain as to whether healthy babies can be born following the use of in vitro fertilization technologies performed in outer space. Furthermore, major safety and ethical concerns must be taken into consideration before such a giant leap for humanity is taken. See also article: Assisted reproduction frontiers in outer space |
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